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Community sources report a 16-week subcutaneous ladder of 250 mcg daily for Weeks 1-4, 375 mcg daily for Weeks 5-8, and 500 mcg daily for Weeks 9-16, but this is reported research context, not a recommendation

Notably, the WHI randomized trials (163, 168) and a meta-analysis (169) have demonstrated that treatment with CEE alone significantly decreases the risk of breast cancer

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